Different Angiogenic Potentials of Mesenchymal Stem Cells Derived from Umbilical Artery, Umbilical Vein, and Wharton's Jelly

Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs),...

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Veröffentlicht in:	Stem Cells International 2017-01, Vol.2017 (2017), p.1-15-68
Hauptverfasser:	Sun, Haixiang, Ding, Lijun, Peault, Bruno, Diao, Zhenyu, Jiang, Ruiwei, Wang, Lei, Liu, Yong, Liu, Jingyu, Zhou, Jianjun, Xu, Lu, Yan, Guijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Analysis Angiogenesis Arteries Biocompatibility Biomedical materials Compartments Differentiation Hospitals In vitro methods and tests Ischemia Jagged1 protein Maturation Medical schools Mesenchymal stem cells Mesenchyme Neovascularization Notch protein Osteoblastogenesis Osteoblasts Penicillin Polymerase chain reaction Stem cells Umbilical arteries Umbilical cord Umbilical vein Veins Veins & arteries
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Zusammenfassung:	Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem cells derived from umbilical vein (UCV-PSCs), and mesenchymal stem cells derived from Wharton’s jelly (WJ-MSCs). These cells had the similar phenotype and differentiation potential toward adipocytes, osteoblasts, and neuron-like cells. However, UCA-PSCs and UCV-PSCs had more CD146+ cells than WJ-MSCs (P
ISSN:	1687-966X 1687-9678 1687-9678
DOI:	10.1155/2017/3175748