Hypoglycemic effect of polysaccharides of Dendrobium officinale compound on type 2 diabetic mice

[Display omitted] •DOCP had a significant hypoglycemic effect on type 2 diabetic mice.•DOCP improved intestinal flora in type 2 diabetic mice.•DOCP reduced liver and pancreas damage in type 2 diabetic mice.•DOCP induced regulation of the expression of metabolism-related genes. This study investigate...

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Veröffentlicht in:	Journal of functional foods 2023-07, Vol.106, p.105579, Article 105579
Hauptverfasser:	Li, Chen, Wang, Yunwei, Huang, Zijia, Zhang, Yi, Li, Jiao, Zhang, Qing, Simpson, Benjamin Kofi, Wang, Jingxue
Format:	Artikel
Sprache:	eng
Schlagworte:	Dendrobium officinale compound Gene expression Hypoglycemic and hypolipidemic effects Intestinal microorganisms Polysaccharides
Online-Zugang:	Volltext
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Zusammenfassung:	[Display omitted] •DOCP had a significant hypoglycemic effect on type 2 diabetic mice.•DOCP improved intestinal flora in type 2 diabetic mice.•DOCP reduced liver and pancreas damage in type 2 diabetic mice.•DOCP induced regulation of the expression of metabolism-related genes. This study investigated the hypoglycemic effect of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. Compared with the model group, the fasting blood glucose value of DOCP (800 mg/kg) at day 35 of the study significantly decreased (P
ISSN:	1756-4646 2214-9414
DOI:	10.1016/j.jff.2023.105579