Noninvasive electromyometrial imaging of human uterine maturation during term labor

Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects’ clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression. Preventing preterm birth and labor arrest requires safe and accurate uterine contraction monitoring. Here, the authors show that Electromyometrial Imaging (EMMI) can image 3D uterine contraction patterns dynamically in human labor, providing new insights into uterine maturation as labor progresses.