Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis

The paraoxonase (PON) gene family includes three members, PON1, PON2 and PON3, aligned in tandem on chromosome 7 in humans and on chromosome 6 in mice. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been impl...

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Veröffentlicht in:	Lipids in health and disease 2012-07, Vol.11 (1), p.92-92, Article 92
Hauptverfasser:	Farid, Ayman Samir, Horii, Yoichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryldialkylphosphatase - genetics Aryldialkylphosphatase - metabolism Aryldialkylphosphatase - physiology Atherosclerosis Atherosclerosis - enzymology Atherosclerosis - etiology Atherosclerosis - immunology Bacterial Infections - enzymology Bacterial Infections - immunology Biosynthesis Cholesterol Chromosomes Communicable diseases Cytokines Enzymes Gene Expression Regulation Genetic aspects Homocysteine Humans Immunity, Innate Infections Infectious diseases Lipoproteins Oxidative stress Paraoxonases Parasitic Diseases - enzymology Parasitic Diseases - immunology Physiological aspects Proteins Review Risk factors Rodents Studies Veins & arteries Virus Diseases - enzymology Virus Diseases - immunology
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Zusammenfassung:	The paraoxonase (PON) gene family includes three members, PON1, PON2 and PON3, aligned in tandem on chromosome 7 in humans and on chromosome 6 in mice. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been implicated in the pathogenesis of several inflammatory diseases, particularly atherosclerosis. The major goal of this review is to highlight the modulation of each of the PONs by infective (bacterial, viral and parasitic) agents, which may shed a light on the interaction between infectious diseases and PONs activities in order to effectively reduce the risk of developing atherosclerosis.
ISSN:	1476-511X 1476-511X
DOI:	10.1186/1476-511x-11-92