P300 cognitive assessment in patients with first-episode psychosis: a prospective case-control study

Background Several studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude. P300 follow-up studies in patients with schizophrenia receiving antipsychotic treatment revealed that the P...

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Veröffentlicht in:Middle East current psychiatry (Cairo) 2020-06, Vol.27 (1), p.1-8, Article 23
Hauptverfasser: Hassan, Wageeh A., Darweesh, Alaa Eldin M., Abdel-Rahman, Ahmed A., Ahmad, Hossam Eddin Khalifa, Hassaan, Shehab H., Noaman, Mostafa M., Fahmy, Iman F. G.
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Sprache:eng
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Zusammenfassung:Background Several studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude. P300 follow-up studies in patients with schizophrenia receiving antipsychotic treatment revealed that the P300 amplitudes were increased while other studies showed limited changes in the P300 amplitude even after antipsychotics use. Results We found that at the first presentation, all patients’ groups have significantly lower amplitude and more prolonged latency of P300 than controls. All the first-episode psychosis patients showed a significant improvement of P300 amplitude mean scores after 1 year, but with no significant change in the P300 latency. There was an inverse correlation between the patients’ PANSS scores and their P300 latency and amplitude values. Conclusion P300 amplitude and latency might be of clinical value in the evaluation of cognitive functions in the first-episode psychosis patients. The abnormalities in P300 may be improved with continuous control of psychotic symptoms with psychotropic medications.
ISSN:2090-5416
2090-5408
2090-5416
DOI:10.1186/s43045-020-00031-2