A Review of Electroactive Nanomaterials in the Detection of Nitrogen-Containing Organic Compounds and Future Applications

Electrochemical and impedimetric detection of nitrogen-containing organic compounds (NOCs) in blood, urine, sweat, and saliva is widely used in clinical diagnosis. NOC detection is used to identify illnesses such as chronic kidney disease (CKD), end-stage renal disease (ESRD), cardiovascular complications, diabetes, cancer, and others. In recent years, nanomaterials have shown significant potential in the detection of NOCs using electrochemical and impedimetric sensors. This potential is due to the higher surface area, porous nature, and functional groups of nanomaterials, which can aid in improving the sensing performance with inexpensive, direct, and quick-time processing methods. In this review, we discuss nanomaterials, such as metal oxides, graphene nanostructures, and their nanocomposites, for the detection of NOCs. Notably, researchers have considered nanocomposite-based devices, such as a field effect transistor (FET) and printed electrodes, for the detection of NOCs. In this review, we emphasize the significant importance of electrochemical and impedimetric methods in the detection of NOCs, which typically show higher sensitivity and selectivity. So, these methods will open a new way to make embeddable electrodes for point-of-detection (POD) devices. These devices could be used in the next generation of non-invasive analysis for biomedical and clinical applications. This review also summarizes recent state-of-the-art technology for the development of sensors for on-site monitoring and disease diagnosis at an earlier stage.