Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer

This study aimed to evaluate the significance of homocysteine (HCY) levels in predicting recurrence-free survival (RFS) and overall survival (OS) in colorectal cancer (CRC) patients. This retrospective study involved 1272 CRC patients. The risk of mortality increased with increasing HCY levels in CR...

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Veröffentlicht in:	Scientific reports 2024-05, Vol.14 (1), p.10057-10057, Article 10057
Hauptverfasser:	Xie, Hailun, Wei, Lishuang, Wang, Qiwen, Tang, Shuangyi, Gan, Jialiang
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/1503 692/699/67 Adult Aged Aged, 80 and over Biomarkers, Tumor - blood Carcinoembryonic antigen Carcinoembryonic Antigen - blood Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease-Free Survival Female Homocysteine Homocysteine - blood Humanities and Social Sciences Humans Male Malnutrition Medical prognosis Metastases Middle Aged Mortality risk multidisciplinary Multivariate analysis Neoplasm Recurrence, Local - blood Neoplasm Staging Nomogram Nomograms Prognosis Prognostic Retrospective Studies Science Science (multidisciplinary) Survival
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Zusammenfassung:	This study aimed to evaluate the significance of homocysteine (HCY) levels in predicting recurrence-free survival (RFS) and overall survival (OS) in colorectal cancer (CRC) patients. This retrospective study involved 1272 CRC patients. The risk of mortality increased with increasing HCY levels in CRC patients. The optimal HCY cutoff value in CRC patients was 15.2 μmol/L. The RFS (45.8% vs. 60.5%, p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-60855-4