Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype

We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by t...

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Veröffentlicht in:	Emerging infectious diseases 2011-06, Vol.17 (6), p.1091-1094
Hauptverfasser:	Accou-Demartin, Marie, Gaborieau, Valérie, Song, Yajun, Roumagnac, Philippe, Marchou, Bruno, Achtman, Mark, Weill, François-Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology bacteria Bacteriology Ciprofloxacin Codon Disease susceptibility Dispatch Drug Resistance, Bacterial Drug Resistance, Bacterial - genetics Gene Expression Regulation, Bacterial Gene Expression Regulation, Bacterial - drug effects Genes, Bacterial Genes, Bacterial - genetics Genetic aspects gyrB Haplotypes Humans Life Sciences Microbial Sensitivity Tests Microbiology and Parasitology Mutation Mutation - genetics Phenotype Quinolones Quinolones - pharmacology Salmonella Salmonella typhi Salmonella typhi - drug effects Salmonella typhi - genetics treatment failure Typhoid Fever Typhoid Fever - microbiology
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Zusammenfassung:	We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1706.101242