Towards the Directed Evolution of Hybrid Catalysts

Towards the Directed Evolution of Hybrid Catalysts

The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and Rh-complexes of dipyridine derivatives as well as the i...

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Veröffentlicht in:Chimia 2002-12, Vol.56 (12), p.721
Hauptverfasser: Reetz, Manfred T., Rentzsch, Martin, Pletsch, Andreas, Maywald, Matthias
Format: Artikel
Sprache:eng
Schlagworte:
Chemical modification
Directed evolution
Enzymes
Hybrid catalysts
Transition metal catalysis
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Zusammenfassung:The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and Rh-complexes of dipyridine derivatives as well as the implantation of a diphosphine moiety in a protein, future steps being cycles of mutagenesis/screening.
ISSN:0009-4293
2673-2424
DOI:10.2533/000942902777679920