New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes

New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5be...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2007-08, Vol.12 (8), p.2029-2037
Hauptverfasser: Xu, Lan-Lan, Zou, Kun, Wang, Jun-Zhi, Wu, Jun, Zhou, Yuan, Dan, Fei-Jun, Yang, Jing
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carbon
Chromatography
Convallarieae
Furostanol Saponins
Liliaceae
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Macrophages - metabolism
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Rats
Rhizome - chemistry
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Tupistra chinensis Bak
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Zusammenfassung:Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.
ISSN:1420-3049
1420-3049
DOI:10.3390/12082029