Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge

Six new bis(indole) alkaloids ( - ) along with eight known ones of the topsentin class were isolated from a sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D ( - ) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A ( ) and B ( ). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.