Association of the 5HTR2C gene Ser23 variation with childhood allergic asthma

: Allergic asthma is the most frequently observed subtype of individuals with asthma. The effects of serotonin plays in the pathophysiology of asthma has not been clearly determined. Thus, this study aimed to investigate the association between the gene rs 6318 G>C polymorphism and allergic asthma in pediatric patients in Cyprus. : This study included total number of 177 individuals with 118 control and 59 pediatric patients (43 atopic and 16 non-atopic asthma patient). A skin prick test was performed for each patient to confirm asthma diagnosis and to evaluate atopic status. Genotyping for the 5HTR2C was completed by Real Time-PCR analysis. : The genotype distribution frequencies were not in agreement with the Hardy-Weinberg Equilibrium in the patients’ group (p