Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism

Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism

Extracellular particles (EPs) including extracellular vesicles (EVs) and exomeres play significant roles in diseases and therapeutic applications. However, their spatiotemporal dynamics in vivo have remained largely unresolved in detail due to the lack of a suitable method. Therefore, a bioluminesce...

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Veröffentlicht in:Advanced science 2020-10, Vol.7 (19), p.2001467-n/a
Hauptverfasser: Wu, Anthony Yan‐Tang, Sung, Yun‐Chieh, Chen, Yen‐Ju, Chou, Steven Ting‐Yu, Guo, Vanessa, Chien, Jasper Che‐Yung, Ko, John Jun‐Sheng, Yang, Alan Ling, Huang, Hsi‐Chien, Chuang, Ju‐Chen, Wu, Syuan, Ho, Meng‐Ru, Ericsson, Maria, Lin, Wan‐Wan, Cheung, Chantal Hoi Yin, Juan, Hsueh‐Fen, Ueda, Koji, Chen, Yunching, Lai, Charles Pin‐Kuang
Format: Artikel
Sprache:eng
Schlagworte:
Biodistribution
Bioluminescence
bioluminescence resonance energy transfer
Communication
exomeres
exosomes
Extracellular vesicles
Labeling
Membranes
Microscopy
microvesicles
Peptides
Plasma
Proteins
redirected tropism
Tomography
Visualization
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Zusammenfassung:Extracellular particles (EPs) including extracellular vesicles (EVs) and exomeres play significant roles in diseases and therapeutic applications. However, their spatiotemporal dynamics in vivo have remained largely unresolved in detail due to the lack of a suitable method. Therefore, a bioluminescence resonance energy transfer (BRET)‐based reporter, PalmGRET, is created to enable pan‐EP labeling ranging from exomeres (
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202001467