Effects of Ascorbic Acid on Aspartame Induced Nephrotoxicity: An Experimental Rat Model

Objective: To assess the nephroprotective role of Ascorbic Acid against Aspartame induced nephrotoxicity in Albino Wistar rats. Study Design: Quasi-experimental study. Place and Duration of Study: Postgraduate research laboratory at ISRA University, Hyderabad from August 2018 until November 2018. Ma...

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Veröffentlicht in:	J. Islamic Int. Med. Coll. 2021-12, Vol.15 (2), p.88-93
1. Verfasser:	Sana Kashif , Kumayl Abbas Meghji , Tariq Feroz Memon , Shazia Parveen Channar , Jahanzeb Khan , Muhammad Shahab Hanif
Format:	Artikel
Sprache:	eng
Schlagworte:	ascorbic acid, aspartame, biochemical, histological, nephrotoxicity
Online-Zugang:	Volltext
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Zusammenfassung:	Objective: To assess the nephroprotective role of Ascorbic Acid against Aspartame induced nephrotoxicity in Albino Wistar rats. Study Design: Quasi-experimental study. Place and Duration of Study: Postgraduate research laboratory at ISRA University, Hyderabad from August 2018 until November 2018. Materials and Methods: Thirty albino Wistar rats were divided into three groups: Group I (Control group), Group II (Aspartame only), and Group III (aspartame and ascorbic acid combination). Pre and post-experiment body weight, the biochemical analysis was done through ANOVA. While Fisher's exact test was used for histological analysis in SPSS version 22. Results: Statistically significant difference in mean post-experimental body weight was observed in all three groups (P-value
ISSN:	1815-4018 2410-5422