Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors

Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors

To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. We enrolled 99 surgical specimens of supratentorial astr...

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Veröffentlicht in:Acta cirurgica brasileira 2013-01, Vol.28 (1), p.48-54
Hauptverfasser: Heinke, Thaís, Espiríto Santo, Kleber Simões do, Longatto Filho, Adhemar, Stavale, João Norberto
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Distribution
Aged
Astrocytoma - pathology
Biomarkers, Tumor - metabolism
Female
Glioma
Humans
Immunohistochemistry
Male
Microvessels - pathology
Neoplasm Grading
Neovascularization, Pathologic
Neovascularization, Pathologic - pathology
Proto-Oncogene Proteins c-kit - metabolism
Retrospective Studies
Statistics, Nonparametric
Supratentorial Neoplasms - pathology
Vascular Endothelial Growth Factor A - metabolism
Young Adult
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Zusammenfassung:To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. KIT and VEGF expression correlated with microvascular density (p
ISSN:0102-8650
1678-2674
0102-8650
DOI:10.1590/S0102-86502013000100008