Exploration of the Hygroscopic Factors of Polygonatum odoratum Polysaccharide Based on Stepwise Regression Method and the Development of Its Moisture-resistant Intermediate Tablets

Objective: To investigate the factors affecting the hygroscopicity of Polygonatum odoratum polysaccharide and to develop moisture-resistant intermediate tablets. Methods: The contents of polysaccharide, protein and fructose in Polygonatum odoratum polysaccharide powder and the indicators characterizing the properties of Polygonatum odoratum polysaccharide powder, such as median diameter D50, distribution span, specific surface area, angle of repose, bulk density and tap density were used as the research objects to determine the most critical factors affecting the hygroscopicity of Polygonatum odoratum polysaccharide by stepwise regression method. The prepare tablet method was used to reduce the specific surface area based on the results of the stepwise regression method. In addition, the effects of tablet diameter, diluent and lubricant on the angle of repose, moisture absorption rate, hardness and fragility were investigated through single-factor experiments. On this basis, moisture-resistant intermediate ta