Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome

Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5). The hypokalemic condition was induced by an oral administration of furosemide (200 mg/kg per day) for 3 days, w...

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Veröffentlicht in:	Journal of Pharmacological Sciences 2006, Vol.100(1), pp.88-92
Hauptverfasser:	Chiba, Katsuyoshi, Sugiyama, Atsushi, Watanabe, Kazuo, Takasuna, Kiyoshi, Hashimoto, Keitaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitubercular Agents - toxicity Dogs Drug Evaluation, Preclinical Female fluoroquinolone Fluoroquinolones - toxicity Furosemide Heart Conduction System - drug effects hypokalemia Hypokalemia - chemically induced long QT syndrome Long QT Syndrome - etiology Models, Animal Time Factors
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Zusammenfassung:	Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5). The hypokalemic condition was induced by an oral administration of furosemide (200 mg/kg per day) for 3 days, which decreased the serum potassium concentration from 3.65 ± 0.13 to 2.35 ± 0.13 mM (P
ISSN:	1347-8613 1347-8648
DOI:	10.1254/jphs.SCJ05008X