Exosomes as miRNA Carriers: Formation-Function-Future

Exosomes as miRNA Carriers: Formation-Function-Future

Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing unde...

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Veröffentlicht in:International journal of molecular sciences 2016-12, Vol.17 (12), p.2028-2028
Hauptverfasser: Yu, Xiaojie, Odenthal, Margarete, Fries, Jochen W U
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell growth
cell metabolism
exosome
Exosomes - metabolism
extracellular vesicle
Gene expression
Humans
Liver - metabolism
Metabolism
MicroRNAs
MicroRNAs - metabolism
miRNA
Models, Biological
Neoplasms - diagnosis
Neoplasms - genetics
Review
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Zusammenfassung:Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes' formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17122028