HIGH TOTAL DOSE RADIATION IMPROVES SURVIVAL OF PATIENTS WITH LOCALLY ADVANCED SMALL CELL LUNG CANCER: RESULTS OF SINGLE-CENTRAL RETROSPECTIVE ANALYSIS

The overall survival of patients with locally advanced small cell lung cancer who received at least 2 courses of chemotherapy and external beam radiation therapy at a total dose >50 Gy delivered to the primary tumor was retrospectively studied. Patients were dividedinto 2 groups. Patients in the...

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Veröffentlicht in:Sibirskiĭ onkologicheskiĭ zhurnal 2016-02 (1), p.5-11
Hauptverfasser: Yu. V. Skripchak, G. V. Kononova, S. M. Asakhin, M. L. Levit, T. Yu. Gagarina, I. K. Pushkareva, M. Yu Valkov
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Sprache:rus
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Zusammenfassung:The overall survival of patients with locally advanced small cell lung cancer who received at least 2 courses of chemotherapy and external beam radiation therapy at a total dose >50 Gy delivered to the primary tumor was retrospectively studied. Patients were dividedinto 2 groups. Patients in the standard treatment group (n=71) were treated to 50–58 Gy total dose. The dose escalation group (n=69) was treated to 60–74 Gy. Accelerated fractionation regimen in radiotherapy was more frequently given in dose escalation treatment group. The 1-, 3- and 5-year survival rates in the dose escalated and standard dose groups were respectively 54 % (95 % CI 42–65 %) and 32 % (95 % CI 23–44 %), р=0,11; 25 % (95 % CI 16–36 %) and 1 % (95% CI 0–8 %), р=0,0003; 17 % (95 % CI 10–28 %) and 0 % (95 % CI 0–5 %) (р=0.0007). The median survival was 14 months (95 % CI 10–17 months) in the dose escalated treatment group and 9 months (95 % CI 8–11months) in patients of the standard treatment group (χ2=16,8, р
ISSN:1814-4861
2312-3168