Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity

The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity. We initially assessed association of five single nuc...

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Veröffentlicht in:BMC medical genetics 2010-01, Vol.11 (1), p.2-2, Article 2
Hauptverfasser: Müller, Timo D, Brönner, Günter, Wandolski, Melanie, Carrie, Jophia, Nguyen, Trang T, Greene, Brandon H, Scherag, André, Grallert, Harald, Vogel, Carla Ig, Scherag, Susann, Rief, Winfried, Wichmann, Hans-Erich, Illig, Thomas, Schäfer, Helmut, Hebebrand, Johannes, Hinney, Anke
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Alleles
Amidohydrolases - genetics
Body Mass Index
Case-Control Studies
Child
Cohort Studies
Enzymes
Epidemiology
Female
Gene mutations
Genetic aspects
Genotype
Health aspects
Humans
Hydrolases
Male
Middle Aged
Mutation
Obesity
Obesity - genetics
Physiological aspects
Polymorphism, Single Nucleotide
Risk factors
Single nucleotide polymorphisms
Studies
Teenagers
Young Adult
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Zusammenfassung:The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity. We initially assessed association of five single nucleotide polymorphisms (SNPs) in FAAH with early onset extreme obesity in up to 521 German obese children and both parents. SNPs with nominal p-values
ISSN:1471-2350
1471-2350
DOI:10.1186/1471-2350-11-2