Preparation and Preliminary Imaging Evaluation of a Group of Novel Rapid 99mTc-Labeled Boric Acid Derivatives Tracers for Myocardial Perfusion Imaging

Nuclear cardiology plays an important role in management of cardiac patients with known or suspected coronary artery disease (CAD). CAD is the leading cause of premature death and permanent disability. Myocardial perfusion imaging (MPI) with radiotracers is a non-invasive technique that shows the heart function and the areas of perfusion defects. In order to evaluate perfusion defects accurately, the radiotracer used in MPI studies must be taken up into myocardium in proportion to the regional myocardial blood flow. At present, 99mTc-TEBO is commonly used in clinic for rapid myocardial perfusion imaging, which has high initial uptake but poor myocardial retention, so it is necessary to optimize its structure. In this study, a group of novel 99mTc-labeled rapid boric acid derivatives tracers for myocardial perfusion imaging, including 99mTc-2SP, 99mTc-4LPA and 99mTc-2MDM were prepared in this study. The preparation time of these tracers was 30 min, and all of them were colorless clear liquid. The radiochemical