Evaluation of serum oxidative stress levels and antioxidant capacity in prediabetes

•TAS levels are lower in prediabetes patients compared to the healthy controls.•TOS levels are significantly increased in patients with prediabetes compared to the healthy subjects.•Both TAS and TOS were correlated with metabolic and renal markers.•Both TAS and TOS had high sensitivity and specifici...

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Veröffentlicht in:Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe 2024-08, Vol.12, p.100106, Article 100106
Hauptverfasser: Balci, Buse, Tekce, Buket Kin, Aktas, Gulali
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Sprache:eng
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Zusammenfassung:•TAS levels are lower in prediabetes patients compared to the healthy controls.•TOS levels are significantly increased in patients with prediabetes compared to the healthy subjects.•Both TAS and TOS were correlated with metabolic and renal markers.•Both TAS and TOS had high sensitivity and specificity in determining prediabetes.•Considering TAS, weight, triglyceride, and GFR, serum TOS level appears as an independent marker of prediabetes. Prediabetes is a metabolic disorder marked by blood sugar levels that are elevated than usual but not yet high enough to be classified as type 2 diabetes. It is known that raised oxidative stress and insufficient antioxidant status play a role in the pathogenesis of type 1 and type 2 diabetes. In this study, we aimed to measure total oxidative stress and antioxidant status in prediabetic patients and compare them with healthy volunteers. Subjects with prediabetes according to their HbA1c and blood sugar levels in their routine tests were included in the study. The control group consisted of healthy volunteers who visited our clinics for routine health screening and had no health problems. TAS and TOS levels of the groups were compared. Mean TAS and median TOS values ​​were significantly different among study and control groups (p < 0.001 for both). Blood TOS level was a reliable risk factor of prediabetes, taking into account TAS, weight, triglycerides, and GFR. Higher oxidative stress and lower antioxidant levels were found in prediabetic patients compared to healthy ones. Diabetes development and related complications can be prevented by interventions for these markers in serum.
ISSN:2667-1379
2667-1379
DOI:10.1016/j.arres.2024.100106