Genome-wide analysis of DNA methylation in bronchial washings

Genome-wide analysis of DNA methylation in bronchial washings

The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking cessation. DNA methylation was analyzed in bronchial washing samples from 70 NSCLCs and 53 ho...

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Veröffentlicht in:Clinical epigenetics 2018-05, Vol.10 (1), p.65-65, Article 65
Hauptverfasser: Um, Sang-Won, Kim, Yujin, Lee, Bo Bin, Kim, Dongho, Lee, Kyung-Jong, Kim, Hong Kwan, Han, Joungho, Kim, Hojoong, Shim, Young Mog, Kim, Duk-Hwan
Format: Artikel
Sprache:eng
Schlagworte:
Bronchial washing
Bronchoalveolar Lavage Fluid - chemistry
Cancer
Cancer patients
Carcinoma, Non-Small-Cell Lung - diagnosis
Carcinoma, Non-Small-Cell Lung - genetics
Care and treatment
Case-Control Studies
CpG Islands
Diagnosis
DNA Methylation
Epigenesis, Genetic
Epigenome
Female
Genetic aspects
Genetic transcription
Genome-Wide Association Study - methods
Health aspects
Humans
Hypermethylation
Logistic Models
Lung cancer
Lung cancer, Non-small cell
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Male
Methylation
Promoter Regions, Genetic
Sensitivity and Specificity
Smoking
Smoking - adverse effects
Smoking - genetics
Smoking Cessation
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Beschreibung
Zusammenfassung:The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking cessation. DNA methylation was analyzed in bronchial washing samples from 70 NSCLCs and 53 hospital-based controls using Illumina HumanMethylation450K BeadChip. Methylation levels in these bronchial washings were compared to those in 897 primary lung tissues of The Cancer Genome Atlas (TCGA) data. Twenty-four CpGs (  
ISSN:1868-7075
1868-7083
DOI:10.1186/s13148-018-0498-8