Prevalence of aac(6')-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy

Prevalence of aac(6')-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy

The spread of aac(6')-Ib-cr plasmid-mediated quinolone resistance determinants was evaluated in 197 enterobacterial isolates recovered in an Italian teaching hospital. The aac(6')-Ib-cr gene was found exclusively in Escherichia coli strains. The gene was located on a plasmid which presente...

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Veröffentlicht in:Gut pathogens 2011-08, Vol.3 (1), p.12-12, Article 12
Hauptverfasser: Frasson, Ilaria, Cavallaro, Antonietta, Bergo, Cristina, Richter, Sara N, Palù, Giorgio
Format: Artikel
Sprache:eng
Schlagworte:
aac(6')-Ib-cr
Drug resistance in microorganisms
Enterobacter
Enterobacteriaceae
fluoroquinolones
Genes
Genetic aspects
Gram-negative
Health aspects
Physiological aspects
plasmid-mediated resistance
Quinolone antibacterial agents
Quinolones
Short Report
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Zusammenfassung:The spread of aac(6')-Ib-cr plasmid-mediated quinolone resistance determinants was evaluated in 197 enterobacterial isolates recovered in an Italian teaching hospital. The aac(6')-Ib-cr gene was found exclusively in Escherichia coli strains. The gene was located on a plasmid which presented additional ESBL genes. Most of the clinical strains were clonally related and displayed three point mutations at the topoisomerase level which conferred high resistance to fluoroquinolones.
ISSN:1757-4749
1757-4749
DOI:10.1186/1757-4749-3-12