Synthesis of novel fluorinated 1,5-benzothiazepine derivatives and their biological evaluation as anticancer and antibacterial agent

Synthesis of novel fluorinated 1,5-benzothiazepine derivatives and their biological evaluation as anticancer and antibacterial agent

A series of novel fluorinated 1,5-benzothiazepine derivatives were synthesized, characterized and evaluated for in vitro anticancer and antibacterial activity. The in vitro anticancer activity of the synthesized compounds 4a?h was evaluated against four human cancer cell lines namely lung (A549), br...

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Veröffentlicht in:Journal of the Serbian Chemical Society 2022, Vol.87 (10), p.1109-1116
Hauptverfasser: Bhabal, Sonal, Shaikh, Sarfaraz, Yellapurkar, Ishita, Pavale, Ganesh, Ramana, Mucheli
Format: Artikel
Sprache:eng
Schlagworte:
breast cancer cell line
cancer cell line
in vitro
liver cancer cell line
prostate cancer cell line
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Zusammenfassung:A series of novel fluorinated 1,5-benzothiazepine derivatives were synthesized, characterized and evaluated for in vitro anticancer and antibacterial activity. The in vitro anticancer activity of the synthesized compounds 4a?h was evaluated against four human cancer cell lines namely lung (A549), breast (MCF-7), liver (HEPG2) and prostate (PC-3). Compounds 4c, 4d, 4g and 4h exhibited good activity with GI50
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC210428041B