Differences between familial and sporadic dilated cardiomyopathy: ESC EORP Cardiomyopathy & Myocarditis registry

Differences between familial and sporadic dilated cardiomyopathy: ESC EORP Cardiomyopathy & Myocarditis registry

Aims Dilated cardiomyopathy (DCM) is a complex disease where genetics interplay with extrinsic factors. This study aims to compare the phenotype, management, and outcome of familial DCM (FDCM) and non‐familial (sporadic) DCM (SDCM) across Europe. Methods and results Patients with DCM that were enrol...

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Veröffentlicht in:ESC Heart Failure 2021-02, Vol.8 (1), p.95-105
Hauptverfasser: Asselbergs, Folkert W., Sammani, Arjan, Elliott, Perry, Gimeno, Juan R., Tavazzi, Luigi, Tendera, Michael, Kaski, Juan Pablo, Maggioni, Aldo P., Rubis, Pawel P., Jurcut, Ruxandra, Heliö, Tiina, Calò, Leonardo, Sinagra, Gianfranco, Zdravkovic, Marija, Olivotto, Iacopo, Kavoliūnienė, Aušra, Laroche, Cécile, Caforio, Alida L.P., Charron, Philippe
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age
Alcohol use
Body mass index
Cardiomyopathies
Cardiomyopathy
Cardiomyopathy, Dilated - epidemiology
Cardiomyopathy, Dilated - genetics
Cardiovascular disease
Confidence intervals
Coronary vessels
Diabetes
Dilated cardiomyopathy
Diuretics
Ejection fraction
Europe
Europe - epidemiology
Familial
Genetic
Heart failure
Human health and pathology
Humans
Hypertension
Life Sciences
Medical prognosis
Mutation
Myocarditis
Myocarditis - diagnosis
Myocarditis - epidemiology
Myocarditis - genetics
Original
Original s
Patients
Prognosis
Prospective Studies
Registries
Sporadic
Standard deviation
Variables
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Beschreibung
Zusammenfassung:Aims Dilated cardiomyopathy (DCM) is a complex disease where genetics interplay with extrinsic factors. This study aims to compare the phenotype, management, and outcome of familial DCM (FDCM) and non‐familial (sporadic) DCM (SDCM) across Europe. Methods and results Patients with DCM that were enrolled in the prospective ESC EORP Cardiomyopathy & Myocarditis Registry were included. Baseline characteristics, genetic testing, genetic yield, and outcome were analysed comparing FDCM and SDCM; 1260 adult patients were studied (238 FDCM, 707 SDCM, and 315 not disclosed). Patients with FDCM were younger (P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13100