Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release

Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca ) release and influence myocyte Ca homeostasis and arrhythmias. In cardiac myocytes, RyRs are found in clusters of various sizes and shapes, and RyR cluster size may critically influence normal and arrhythmogenic Ca spark and wave...

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Veröffentlicht in:	Journal of the American Heart Association 2018-06, Vol.7 (13)
Hauptverfasser:	Galice, Samuel, Xie, Yuanfang, Yang, Yi, Sato, Daisuke, Bers, Donald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology calcium regulation Calcium Signaling calcium sparks Computer Simulation Excitation Contraction Coupling Heart Rate Humans Ion Channel Gating Models, Cardiovascular Myocytes, Cardiac - metabolism Original Research Rats, Sprague-Dawley ryanodine receptor Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism
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Zusammenfassung:	Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca ) release and influence myocyte Ca homeostasis and arrhythmias. In cardiac myocytes, RyRs are found in clusters of various sizes and shapes, and RyR cluster size may critically influence normal and arrhythmogenic Ca spark and wave formation. However, the actual RyR cluster sizes at specific Ca spark sites have never been measured in the physiological setting. Here we measured RyR cluster size and Ca sparks simultaneously to assess how RyR cluster size influences Ca sparks and sarcoplasmic reticulum Ca leak. For small RyR cluster sizes (
ISSN:	2047-9980 2047-9980
DOI:	10.1161/JAHA.118.008724