Insulin resistance limits corneal nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control

Aims/Introduction This study aimed to investigate whether insulin resistance (IR) in individuals with type 2 diabetes undergoing intensive glycemic control determines the extent of improvement in neuropathy. Materials and Methods This was an exploratory substudy of an open‐label, randomized controll...

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Veröffentlicht in:	Journal of diabetes investigation 2021-11, Vol.12 (11), p.2002-2009
Hauptverfasser:	Ponirakis, Georgios, Abdul‐Ghani, Muhammad A, Jayyousi, Amin, Zirie, Mahmoud A, Al‐Mohannadi, Salma, Almuhannadi, Hamad, Petropoulos, Ioannis N, Khan, Adnan, Gad, Hoda, Migahid, Osama, Megahed, Ayman, Qazi, Murtaza, AlMarri, Fatema, Al‐Khayat, Fatima, Mahfoud, Ziyad, DeFronzo, Ralph, Malik, Rayaz A
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood pressure Body mass index Cholesterol Clinical Trial Confocal microscopy Cornea Cornea - innervation Corneal confocal microscopy Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diabetic Neuropathies - blood Diabetic Neuropathies - etiology Diabetic Neuropathies - physiopathology Diabetic neuropathy Diabetic peripheral neuropathy Exenatide - administration & dosage Fasting FDA approval Female Glucose Glycated Hemoglobin - drug effects Glycemic Control - methods Hemoglobin High density lipoprotein Homeostasis Humans Hypoglycemic Agents - administration & dosage Insulin Insulin - administration & dosage Insulin resistance Insulin Resistance - physiology Male Metabolism Microscopy, Confocal Middle Aged Nerve Fibers - pathology Nerve Regeneration Pioglitazone Pioglitazone - administration & dosage Plasma Regeneration Regression analysis Treatment Outcome
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Beschreibung
Zusammenfassung:	Aims/Introduction This study aimed to investigate whether insulin resistance (IR) in individuals with type 2 diabetes undergoing intensive glycemic control determines the extent of improvement in neuropathy. Materials and Methods This was an exploratory substudy of an open‐label, randomized controlled trial of individuals with poorly controlled type 2 diabetes treated with exenatide and pioglitazone or insulin to achieve a glycated hemoglobin
ISSN:	2040-1116 2040-1124
DOI:	10.1111/jdi.13582