Inhibitory neurons in the superior colliculus mediate selection of spatially-directed movements

Decision making is a cognitive process that mediates behaviors critical for survival. Choosing spatial targets is an experimentally-tractable form of decision making that depends on the midbrain superior colliculus (SC). While physiological and computational studies have uncovered the functional topographic organization of the SC, the role of specific SC cell types in spatial choice is unknown. Here, we leveraged behavior, optogenetics, neural recordings and modeling to directly examine the contribution of GABAergic SC neurons to the selection of opposing spatial targets. Although GABAergic SC neurons comprise a heterogeneous population with local and long-range projections, our results demonstrate that GABAergic SC neurons do not locally suppress premotor output, suggesting that functional long-range inhibition instead plays a dominant role in spatial choice. An attractor model requiring only intrinsic SC circuitry was sufficient to account for our experimental observations. Overall, our study elucidates the role of GABAergic SC neurons in spatial choice. Essig et al used a combination of behavior, optogenetics, neural recordings and modelling to directly examine the contribution of GABAergic superior colliculus neurons to the selection of opposing spatial targets. They demonstrated that these neurons do not locally suppress premotor output, suggesting that functional long-range inhibition instead plays a dominant role in spatial choice.