Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome

From Service d’hématologie – Greffe (MR, PdL, CF, VR, AD, EG, PR, GS); Laboratoire de virologie (SMJ, CS); Service de maladies infectieuses (JMM); Service de pneumologie (AB); INSERM U728 (GS), Paris, France Correspondence: Prof. Gérard Socié, Hôpital Saint Louis, Service d’Hématologie, Greffe, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France. E-mail: gerard.socie{at}paris7.jussieu.fr We analyzed the factors and outcome of patients with disseminated adenovirus infection (dAdV) after allogeneic hematopoeitic stem cell transplantation (HSCT). Thirty patients with dAdV were identified among 620 allogeneic HSCT recipients. Primary diseases were leukemia (n=17), Fanconi anemia (n=12) or others (n=1). Source of stem cells was unrelated in 28 and related in 2 patients. The graft consisted of peripheral blood (n=3), bone marrow (n=12) and unrelated cord-blood (UCB, n=15). Risk factors for dAdV in unrelated HSCT recipients were previous Fanconi disease ( p =0.03) and GVHD ( p =0.02) in children, and cord blood source of stem cells ( p =0.029) and GVHD (0.024) in adults. Key words: adenovirus infection, allogeneic hemetopoietic stem cell transplantation, risk factors.