Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma

Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma

A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph...

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Veröffentlicht in:Case reports in hematology 2018-01, Vol.2018 (2018), p.1-4
Hauptverfasser: Flavin, Richard, Hayes, Triona, Walker, Jan, Dowling, Anita, Quinn, Fiona, O’Neill, John Patrick, Bird, Brian
Format: Artikel
Sprache:eng
Schlagworte:
Bendamustine
Biopsy
Case Report
Case reports
Hybridization
Immunoglobulins
Leukemia
Lymphatic system
Lymphocytes
Lymphoma
Morphology
Non-Hodgkin's lymphomas
Pathogenesis
Pathology
Polymerase chain reaction
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Beschreibung
Zusammenfassung:A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph node biopsy was notable for the composite presence of two distinct lymphoid neoplasms, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), and follicular lymphoma (FL). Multiplex PCR and FISH analyses failed to demonstrate a t(14;18)(q32;q21) translocation in either composite lymphoma component. A clonal light-chain kappa (V/JC intron-kde) gene rearrangement was detected in the FL component only.
ISSN:2090-6560
2090-6579
DOI:10.1155/2018/4312594