Monoclonal antibodies in rheumatoid arthritis : comparative effectiveness of tocilizumab with tumor necrosis factor inhibitors

Monoclonal antibodies in rheumatoid arthritis : comparative effectiveness of tocilizumab with tumor necrosis factor inhibitors

Highlights current data regarding the comparative efficacy and safety of tocilizumab (TCZ), a humanised anti-IL-6 receptor antibody, and tumour necrosis factor (TNF) inhibitors, then discusses the positions of these agents in the treatment of rheumatoid arthritis (RA). Source: National Library of Ne...

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Veröffentlicht in:Biologics 2014-01, Vol.8 (default), p.141-153
Hauptverfasser: Tanaka, Toshio, Hishitani, Yoshihiro, Ogata, Atsushi
Format: Artikel
Sprache:eng
Schlagworte:
Biologicals
Clinical trials
Cytokines
Cytotoxicity
Disease
Dosage and administration
Drug therapy
Immunoglobulins
Immunosuppressive agents
Immunotherapy
Inflammation
Interleukin-6
Memory
Monoclonal antibodies
Pathogenesis
Physiological aspects
Polyethylene glycol
Review
Rheumatic diseases
Rheumatoid arthritis
Signal transduction
TNF inhibitors
Tocilizumab
Treatment
Tumor necrosis factor
Tumor necrosis factor-TNF
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Zusammenfassung:Highlights current data regarding the comparative efficacy and safety of tocilizumab (TCZ), a humanised anti-IL-6 receptor antibody, and tumour necrosis factor (TNF) inhibitors, then discusses the positions of these agents in the treatment of rheumatoid arthritis (RA). Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons Attribution 3.0 New Zealand Licence.
ISSN:1177-5475
1177-5491
1177-5475
1177-5491
DOI:10.2147/BTT.S37509