Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation

We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer’s disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal kar...

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Veröffentlicht in:Stem cell research 2024-09, Vol.79, p.103495-103495, Article 103495
Hauptverfasser: Elli Clarke, Jordan, Karch, Celeste M., Allegri, Ricardo, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Sus, Brosch, Jared, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chhatwal, Jasmeer, Chua, Jasmin, Courtney, Laura, DeLaCruz, Chrismary, Denner, Darcy, Dincer, Aylin, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne, Farlow, Marty, Fitzpatrick, Colleen, Flores, Shaney, Franklin, Erin, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Gonzalez, Alyssa, Gordon, Brian, Gr¨aber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gremminger, Emily, Groves, Alex, Haass, Christian, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Scott Mason, Neal, Masters, Colin, Mawuenyega, Kwasi, McDade, Eric, Mejia, Arlene, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, Neelesh, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, Patira, Riddhi, Preische, Oliver, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Xiong, Chengjie, Xu, Jinbin
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Cell Differentiation
Cell Line
Gene Editing
Humans
Induced Pluripotent Stem Cells - metabolism
Mutation
Presenilin-1 - genetics
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Beschreibung
Zusammenfassung:We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer’s disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.
ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2024.103495