Contribution of VEGF polymorphism rs3025020 to short stature and hypertension in elderly Japanese individuals: a cross-sectional study

Recently, short stature has been revealed to be positively associated with hypertension, possibly because this indicates lower activity of vascular maintenance, such as angiogenesis. Vascular endothelial growth factor (VEGF) polymorphism (rs3025020) plays an important role in the progression of angi...

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Veröffentlicht in:	Journal of physiological anthropology 2021-02, Vol.40 (1), p.4-4, Article 4
Hauptverfasser:	Shimizu, Yuji, Yamanashi, Hirotomo, Kawashiri, Shin-Ya, Nobusue, Kenichi, Nonaka, Fumiaki, Noguchi, Yuko, Honda, Yukiko, Arima, Kazuhiko, Abe, Yasuyo, Nagata, Yasuhiro, Maeda, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Angiogenesis Antihypertensives Blood pressure Body Height - genetics Bone marrow Cardiovascular agents Cardiovascular diseases Creatinine Cross-Sectional Studies Female Genetic aspects Genotype & phenotype Height Homozygotes Humans Hypertension Hypertension - epidemiology Hypertension - genetics Hypoxia Japan - epidemiology Laboratories Male Middle Aged Original Polymorphism Polymorphism, Single Nucleotide - genetics Population Risk factors rs3025020 Short stature Stature, Short Thermal cycling Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics VEGF
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Zusammenfassung:	Recently, short stature has been revealed to be positively associated with hypertension, possibly because this indicates lower activity of vascular maintenance, such as angiogenesis. Vascular endothelial growth factor (VEGF) polymorphism (rs3025020) plays an important role in the progression of angiogenesis and may be associated with both hypertension and hypertension-associated short stature. A cross-sectional study of 1377 elderly Japanese individuals aged 60-89 years was conducted. Short stature was defined as the lowest tertile of height (
ISSN:	1880-6805 1880-6791 1880-6805
DOI:	10.1186/s40101-021-00253-1