Synthesis of New 2-Arylbenzo[ b ]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media

Synthesis of New 2-Arylbenzo[ b ]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media

A series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized by the Suzuki cross-coupling reactions. The reactions, performed in the presence of K₂CO₃, EtOH/H₂O and Pd(II) complex as catalyst, gave the corresponding products in good to excellent yields. The methodo...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2018-09, Vol.23 (10), p.2450
Hauptverfasser: Chen, Qianqian, Jiang, Panli, Guo, Mengping, Yang, Jianxin
Format: Artikel
Sprache:eng
Schlagworte:
aqueous phase
Benzofurans - chemical synthesis
Benzofurans - chemistry
Carbonates - chemistry
Catalysis
Communication
Ethanol - chemistry
heterobiaryl compounds
Molecular Structure
Palladium - chemistry
palladium(II) complex catalyst
Potassium - chemistry
Suzuki cross-coupling
Water - chemistry
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Zusammenfassung:A series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized by the Suzuki cross-coupling reactions. The reactions, performed in the presence of K₂CO₃, EtOH/H₂O and Pd(II) complex as catalyst, gave the corresponding products in good to excellent yields. The methodology allows the facile production of heterobiaryl compounds, a unique architectural motif that is ubiquitous in medicinal chemistry.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23102450