Longitudinal changes of SARA scale in Friedreich ataxia: Strong influence of baseline score and age at onset

BackgroundThe Scale for Assessment and Rating of Ataxia (SARA) is widely used in different types of ataxias and has been chosen as the primary outcome measure in the European natural history study for Friedreich ataxia (FA).MethodsTo assess distribution and longitudinal changes of SARA scores and it...

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Veröffentlicht in:	Annals of clinical and translational neurology 2023-11, Vol.10 (11), p.2000-2012
Hauptverfasser:	Porcu, Luca, Fichera, Mario, Nanetti, Lorenzo, Rulli, Eliana, Giunti, Paola, Parkinson, Michael H., Durr, Alexandra, Ewenczyk, Claire, Boesch, Sylvia, Nachbauer, Wolfgang, Indelicato, Elisabetta, Klopstock, Thomas, Stendel, Claudia, Rodríguez de Rivera, Francisco Javier, Schöls, Ludger, Fleszar, Zofia, Giordano, Ilaria, Didszun, Claire, Castaldo, Anna, Rai, Myriam, Klockgether, Thomas, Pandolfo, Massimo, Schulz, Jörg B., Reetz, Kathrin, Mariotti, Caterina
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Ataxia Clinical trials Gait Human health and pathology Life Sciences Longitudinal studies Missing data Patients Software
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Zusammenfassung:	BackgroundThe Scale for Assessment and Rating of Ataxia (SARA) is widely used in different types of ataxias and has been chosen as the primary outcome measure in the European natural history study for Friedreich ataxia (FA).MethodsTo assess distribution and longitudinal changes of SARA scores and its single items, we analyzed SARA scores of 502 patients with typical-onset FA (
ISSN:	2328-9503 2328-9503
DOI:	10.1002/acn3.51886