HEMATOLOGICAL PARAMETERS OF HIV-INFECTED PATIENTS IN PROGRESSING IMMUNE DEFICIENCY

A comparative analysis of some immunophysiological and hematological parameters was performed in a group of HIV-infected patients living in a region of Western Siberia (Russia). The study was performed using laboratory, epidemiological and clinical data, within a time period of 1999 through 2009. The HIV-infected persons were classified in two study groups that differed in rates of immunodeficiency progression, with respect to age, duration of HIV-infection, clinical stage of HIV-infection, duration of drug addiction, living terms in the Northern Region, concomitant diseases, as well as timing of immunological and hematological examinations. A significant direct correlation has been revealed between the numbers of CD4-, CD8- lymphocytes, and the levels of total protein and albumin in HIV-infected patients. The study of hematological parameters, as related to progression of immune deficiency, is of mutual medical interest, with respect to general assessment of the patients’ health, like as for clinical and immunological prognosis in HIV infection. (Med. Immunol., 2011, vol. 13, N 1, pp 73-78)