Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications

An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-ba...

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Veröffentlicht in:Cosmetics (Basel) 2019-03, Vol.6 (1), p.16
Hauptverfasser: Shabunin, Anton S., Yudin, Vladimir E., Dobrovolskaya, Irina P., Zinovyev, Evgeny V., Zubov, Viktor, Ivan’kova, Elena M., Morganti, Pierfrancesco
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Sprache:eng
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Zusammenfassung:An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds.
ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics6010016