Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller

HIV-1 controllers are patients who control HIV-1 viral replication without antiretroviral therapy. Control is achieved very early in the course of infection, but the mechanisms through which viral replication is restricted are not fully understood. We describe a patient who presented with acute HIV-...

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Veröffentlicht in:	EBioMedicine 2017-02, Vol.16 (C), p.141-149
Hauptverfasser:	Walker-Sperling, Victoria E., Pohlmeyer, Christopher W., Veenhuis, Rebecca T., May, Megan, Luna, Krystle A., Kirkpatrick, Allison R., Laeyendecker, Oliver, Cox, Andrea L., Carrington, Mary, Bailey, Justin R., Arduino, Roberto C., Blankson, Joel N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence CD4-Positive T-Lymphocytes - immunology CD8 + T cells CD8-Positive T-Lymphocytes - immunology Female HIV controllers HIV Infections - immunology HIV Infections - virology HIV-1 HIV-1 - genetics HIV-1 - immunology HIV-1 - physiology HLA Antigens - genetics HLA Antigens - immunology Host-Pathogen Interactions - immunology Humans Killer Cells, Natural - immunology NK cells Research Paper Sequence Homology, Amino Acid Time Factors Transmission pair Viral Load - genetics Viral Load - immunology Virus Replication - genetics Virus Replication - immunology
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Zusammenfassung:	HIV-1 controllers are patients who control HIV-1 viral replication without antiretroviral therapy. Control is achieved very early in the course of infection, but the mechanisms through which viral replication is restricted are not fully understood. We describe a patient who presented with acute HIV-1 infection and was found to have an HIV-1 RNA level of
ISSN:	2352-3964 2352-3964
DOI:	10.1016/j.ebiom.2017.01.034