Kingianic acids A-G, Endiandric acid analogues from Endiandra kingiana

A phytochemical investigation of the methanolic extract of the bark of Endiandra kingiana led to the isolation of seven new tetracyclic endiandric acid analogues, kingianic acids A-G (1-7), together with endiandric acid M (8), tsangibeilin B (9) and endiandric acid (10). Their structures were determ...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2014-01, Vol.19 (2), p.1732-1747
Hauptverfasser: Azmi, Mohamad Nurul, Gény, Charlotte, Leverrier, Aurélie, Litaudon, Marc, Dumontet, Vincent, Birlirakis, Nicolas, Guéritte, Françoise, Leong, Kok Hoong, Halim, Siti Nadiah Abd, Mohamad, Khalit, Awang, Khalijah
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Sprache:eng
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Zusammenfassung:A phytochemical investigation of the methanolic extract of the bark of Endiandra kingiana led to the isolation of seven new tetracyclic endiandric acid analogues, kingianic acids A-G (1-7), together with endiandric acid M (8), tsangibeilin B (9) and endiandric acid (10). Their structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The structure of compounds 9 and 10 were confirmed by single-crystal X-ray diffraction analysis. These compounds were screened for Bcl-xL and Mcl-1 binding affinities and cytotoxic activity on various cancer cell lines. Compound 5 showed moderate cytotoxic activity against human colorectal adeno-carcinoma (HT-29) and lung adenocarcinoma epithelial (A549) cell lines, with IC50 values in the range 15-17 µM, and compounds 3, 6 and 9 exhibited weak binding affinity for the anti-apoptotic protein Mcl-1.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules19021732