A Proof of Principle Study of the Terminal Sterilization of Prefilled Syringes Using A Water Cascade Process

A Proof of Principle Study of the Terminal Sterilization of Prefilled Syringes Using A Water Cascade Process

A new development in drug compounding is the production of ready-to-administer sterilized prefilled syringes. A challenge with these syringes is the method of terminal sterilization. There is no information available whether water cascade sterilization is a suitable method. We investigated the effec...

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Veröffentlicht in:Pharmaceutical technology in hospital pharmacy 2018-12, Vol.3 (4), p.191-198
Hauptverfasser: Drost-Wijnne, Anne J.A., Van Wezel, Ralph A.C., Deenen, Maarten J., Van Doornmalen Gomez Hoyos, Joost P.C.M., Grouls, René J.E.
Format: Artikel
Sprache:eng
Schlagworte:
compounding
prefilled syringe
ready-to-administer
sterilization
water cascade sterilization
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Zusammenfassung:A new development in drug compounding is the production of ready-to-administer sterilized prefilled syringes. A challenge with these syringes is the method of terminal sterilization. There is no information available whether water cascade sterilization is a suitable method. We investigated the effect of this sterilization method on cyclic olefin (co)polymer (CCP/COC) syringes.
ISSN:2365-2411
2365-242X
DOI:10.1515/pthp-2018-0020