Hepatoprotective activity of Ceriops decandra (Griff.) Ding Hou mangrove plant against CCl4 induced liver damage

In folklore medicine, Ceriops decandra is used to treat hepatitis. However, a scientific evaluation has not been performed. Thus, the present study was carried out to identify the hepatoprotective activity of plant parts (leaf, bark, collar, flower and hypocotyls) of C. decandra. In vitro antioxidant studies were carried out with DPPH, HRSA, NO, FRAP and LPO assays. The LD50 was calculated and in vivo hepatoprotective activity was carried out with the leaf extract, which was found to be the most potent. The in vivo hepatoprotective activity was performed as follows: Group 1, control animals; Group 2, carbon tetrachloride (CCl4)-treated animals; Group 3, silymarin (100mgkg−1 bw p.o.) treated animals; Groups 4, 5 and 6, C. decandra treatment groups (100, 200 and 400mgkg−1 bw). Histopathological scores were calculated with standard protocols. Of the selected different plant parts, the leaf extract showed maximum antioxidant scavenging properties. A study of the oral acute toxicity found C. decandra extract to be non-toxic up to 2000mgkg−1 bw. The in vivo hepatoprotective nature of the leaf extract was identified as dose dependent and the levels of SGOT, SGPT, ALP, bilirubin, CHL and LDH were found to be significantly decreased (p