Cytotoxicity Evaluation of Novel bis(2-aminoethyl)amine Derivatives

Seven novel derivatives of bis(2-aminoethyl)amine were synthesized. For compounds and single crystals were isolated and X-ray diffraction experiments were done. Lipophilicity and drug likeness were calculated in the initial stage of research. All compounds were screened for their in vitro cytotoxic activity against a panel of human cancer cell lines, which is contrary to normal (HaCaT) cell lines, by using the MTT method. Studies were followed by lactate dehydrogenase assay, apoptotic activity, and interleukin-6 assay. Within the studied group, compound showed the most promising results in all biological studies. The strongest influence in A549 cells was denoted for derivative , which inhibited interleukin release almost tenfold, as compared to the control.