Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica

•Effect of agitation and solvent percent on A. gangetica extraction was evaluated.•RSM is a crucial tool to determine optimum condition for phytochemical extraction.•Phytochemical compounds are useful in food and pharmaceuticals industries. This study aims to investigate the influence of agitation and solvent percentage on the phytochemical extraction from Asystasia gangetica through response surface methodology and to optimize the extraction condition. The experiment was conducted based on the central composite design with two variables: solvent percentage and agitation speed. The total phenolic compound (Folin–Ciocalteu method), total flavonoid compound (Dowd method), and antioxidant activity (modified DPPH free radical scavenging assay), were analyzed through the analysis of variance. All models were significant (p-value