Effect of xanthan-based CHLO-SITE chlorhexidine gel with scaling and root planing on the treatment of periodontitis

Introduction: Nowadays, various antibiotics and antiseptics are used as locally delivered adjuncts to scaling and root planing (SRP) in the treatment of periodontitis. The aim of this study was to evaluate the clinical efficacy of xanthan-based CHLO-SITE gel (xan-CHX) as a local adjunctive therapy to SRP in the treatment of moderate-to-severe periodontitis.Materials and Methods: In this controlled clinical trial, 6 patients with moderate-to-severe chronic periodontitis were selected. Each subject had at least three pockets 4-7 mm deep. Twenty-eight randomly selected pockets were assigned to the control group and 44 pockets were assigned to the test group. Scaling and root planing (SRP) procedures were carried out in all the pockets. In the test group, in addition to SRP, xan-CHL gel was injected into the pockets. Clinical indices (PPD, CAL, BOP, PI) before and three months after treatment were measured and evaluated by paired t-test, chi-squared and Kruskal-Wallis testes using SPSS software.Results: At baseline, there were no significant differences between the control and experimental sites in relation to the indices measured. After 3 mouths, means of PPD and BOP in the experimental sites were significantly lower compared to control sites (p value ≤ 0.05). Mean of CAL in the experimental sites was significantly higher than that in control sites (p value ≤ 0.05).Conclusion: The results of this study revealed that injection of xan-CHL gel with SRP has better clinical efficacy than SRP alone in the treatment of periodontitis. Key words: Chlorhexidine, Locally delivered medications, Periodontitis.