Predicting Aqueous Solubility of Chlorinated Hydrocarbons by the MCI Approach

Correlation for estimation of the aqueous solubility (logSw) of chlorinatedhydrocarbons molecules is proposed. The MCI based quantitative structure-propertyrelationship (QSPR) model proposed is predictive and requires only three connectivityindices in the calculation. The correlation equation obtain...

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Veröffentlicht in:International journal of molecular sciences 2006-02, Vol.7 (2), p.47-58
Hauptverfasser: Wang, Ying-Long, Hu, Yang-Dong, Wu, Lian-Ying, An, Wei-Zhong
Format: Artikel
Sprache:eng
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Zusammenfassung:Correlation for estimation of the aqueous solubility (logSw) of chlorinatedhydrocarbons molecules is proposed. The MCI based quantitative structure-propertyrelationship (QSPR) model proposed is predictive and requires only three connectivityindices in the calculation. The correlation equation obtained which is based on a training setof 50 chlorinated hydrocarbons has a correlation coefficient of 0.9670 and a standard errorof 0.44 log10 units. Application of the developed model to a testing set of 73 chlorinatedhydrocarbons demonstrates that the new model is reliable with good predictive accuracy andsimple formulation. Besides, the model does not require any experimental physicochemicalproperties in the calculation, so it is easy to apply, especially in cases where it isinconvenient or impossible to measure the physicochemical properties.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/i7020047