Analysis of multimodal ultrasonic characteristics in breast cancer with human epidermal growth factor receptor 2 positive under different expression status of hormone receptor2

"Objective To analyze multimodal ultrasonic characteristics of human epidermal growth factor receptor 2 (HER-2) positive breast cancer patients in different hormone receptor (HR) expression states, so as to provide a reference for the early diagnosis and treatment of HER-2 positive breast cancer. Methods The clinical data of 160 patients with HER-2 positive breast cancer who were diagnosed and treated in the First Affiliated Hospital with Nanjing Medical University and Jurong Peoples Hospital from January 2017 to December 2023 were collected retrospectively. According to immunohistochemical results, patients were divided into HR positive group (n=89) and HR negative group (n=71). General data, pathological characteristics and multimodal ultrasonic characteristics of the two groups were compared. Logistic regression analysis was performed to analyze the relationship between multimodal ultrasonic characteristics and HR expression in HER-2 positive breast cancer. The receiver operating characteristic (ROC) curv