Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor

The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein. This review retraces the history of the difficulties and successes in the identification of the...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2020-04, Vol.10 (4), p.547
1. Verfasser:	Changeux, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Discovery and exploration Drug Discovery Electric instruments Enzymes first identification of a receptor history of neuroscience Humans Investigations Ligands Nicotine nicotinic acetylcholine receptor Nicotinic receptors pharmacological receptor Physiological aspects Physiology Proteins Receptors, Nicotinic - chemistry Receptors, Nicotinic - metabolism Review Signal transduction
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Beschreibung
Zusammenfassung:	The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein. This review retraces the history of the difficulties and successes in the identification of the nicotinic acetylcholine receptor, the first neurotransmitter receptor to be identified.
ISSN:	2218-273X 2218-273X
DOI:	10.3390/biom10040547