Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report
Background Focal nodular hyperplasia (FNH) is typically considered a benign tumor of the liver without malignant potential. The co-occurrence of FNH and hepatocellular carcinoma (HCC) has been reported in rare cases. In this study we sought to investigate the clonal relationship between these lesion...
Gespeichert in:
Veröffentlicht in: | Communications medicine 2022-02, Vol.2 (1), p.11-11, Article 11 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Background
Focal nodular hyperplasia (FNH) is typically considered a benign tumor of the liver without malignant potential. The co-occurrence of FNH and hepatocellular carcinoma (HCC) has been reported in rare cases. In this study we sought to investigate the clonal relationship between these lesions in a patient with FNH-HCC co-occurrence.
Methods
A 74-year-old female patient underwent liver tumor resection. The resected nodule was subjected to histologic analyses using hematoxylin and eosin stain and immunohistochemistry. DNA extracted from microdissected FNH and HCC regions was subjected to whole exome sequencing. Clonality analysis were performed using PyClone.
Results
Histologic analysis reveals that the nodule consists of an FNH and two adjoining HCC components with distinct histopathological features. Immunophenotypic characterization and genomic analyses suggest that the FNH is clonally related to the HCC components, and is composed of multiple clones at diagnosis, that are likely to have progressed to HCC through clonal selection and/or the acquisition of additional genetic events.
Conclusion
To the best of our knowledge, our work is the first study showing a clonal relationship between FNH and HCC. We show that FNH may possess the capability to undergo malignant transformation and to progress to HCC in very rare cases.
Ercan et al. report clinical, pathological and molecular findings from a patient with focal nodular hyperplasia (FNH) in the liver with concomitant hepatocellular carcinomas (HCC). Genomic analysis performed by the authors suggests that FNH might progress to HCC in very rare cases.
Plain language summary
Focal nodular hyperplasia (FNH) is a lesion resulting from the abnormal growth of liver cells. It is typically considered a benign tumor that does not become malignant. In rare cases, FNH may occur alongside malignant hepatocellular carcinoma (HCC). In these cases, it is not known whether the malignant HCC may derive from the benign FNH. In this study, we reported on the analysis of a 74-year-old female patient with co-occurring FNH and HCC. We found that the FNH and HCC lesions were in fact genetically related, suggesting that the FNH gave rise to the HCC lesions. Furthermore, we found multiple cell populations within the FHN lesion that may be precursors to the HCC lesions suggesting that, in rare cases, FNH may be capable of progressing to malignant HCC. These findings may help to refine the surveillance strategy for these lesio |
---|---|
ISSN: | 2730-664X 2730-664X |
DOI: | 10.1038/s43856-022-00074-y |