Optimizing vaccination strategies in an age structured SIR model

We present a modeling framework based on a structured SIR model where different vaccination strategies can be tested and compared. Vaccinations can be dosed at prescribed ages or at prescribed times to prescribed portions of the susceptible population. Different choices of these prescriptions lead t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mathematical Biosciences and Engineering 2020-01, Vol.17 (2), p.1074-1089
Hauptverfasser: Colombo, Rinaldo M, Garavello, Mauro
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We present a modeling framework based on a structured SIR model where different vaccination strategies can be tested and compared. Vaccinations can be dosed at prescribed ages or at prescribed times to prescribed portions of the susceptible population. Different choices of these prescriptions lead to entirely different evolutions of the disease. Once suitable "costs" are introduced, it is natural to seek, correspondingly, the "best" vaccination strategies. Rigorous results ensure the Lipschitz continuous dependence of various reasonable costs on the control parameters, thus ensuring the existence of optimal controls and suggesting their search, for instance, by means of the steepest descent method.
ISSN:1551-0018
1551-0018
DOI:10.3934/mbe.2020057